Wholesome in bulk™ L-Tyrosine Powder, Free Form Amino Acid
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Bulk L-Tyrosine Powder for Supplement Manufacturing
L-tyrosine is a free form amino acid powder made by microbial fermentation or other industrial routes, sold as fine white crystals (CAS 60-18-4). It is a different compound from N-acetyl-L-tyrosine. We supply it in bulk to supplement brands, contract manufacturers, and formulators. You can request testing documents and samples on the quote form.
A single amino acid with a clear specification
L-tyrosine is easy to specify. It is one named compound with a CAS number, a USP grade market, and standard tests for identity and purity. That makes lot to lot comparison simple for buyers and quality teams.
One named compound
L-tyrosine has the formula C9H11NO3 and a molecular weight of 181.19. It is sold without a salt partner, so a 99% assay means about 99% of the powder is tyrosine.
Optical identity you can check
Specific rotation confirms the L-form. Published specifications call for about −9.8° to −11.2°, and a racemic DL material would read near zero.
Not the same as NALT
N-acetyl-L-tyrosine (CAS 537-55-3) is a separate compound with an acetyl group added. By weight it is about 81% tyrosine, so the two are not swapped gram for gram.
Low water solubility
L-tyrosine dissolves poorly in plain water and stays as a fine suspension. That suits capsules, tablets, and dry blends, while drink mixes need suspension trials.
White crystals for dry blending
Good lots are white crystalline powder or fine needles. Ask for the mesh size that suits your capsule filler or tablet press.
A listed food additive
21 CFR 172.320 lists L-tyrosine for use in conventional foods, up to 4.3% of total protein, with Food Chemicals Codex specs. Dietary supplements follow separate rules.
Where formulators use L-tyrosine powder
Free form L-tyrosine fits measured formats where fill weight and serving size are controlled, including:
- Capsules
- Compressed tablets
- Single ingredient powders
- Multiple ingredient amino acid blends
- Sports nutrition powders
- Stick packs and sachets
- Powdered drink mixes, after suspension trials
- Private label programs
Plan fill weights from the confirmed assay on each COA. L-tyrosine and N-acetyl-L-tyrosine are not interchangeable gram for gram, so recalculate your serving math whenever you switch forms.
What to check before you buy L-tyrosine
Powders sold as tyrosine can differ in compound, source, purity limits, and how carefully the spec was written. Review these points together, and ask for lot documents before you approve a supplier.
L-tyrosine or NALT
Confirm that the specification and certificate of analysis (COA) both name L-tyrosine, CAS 60-18-4. N-acetyl-L-tyrosine, CAS 537-55-3, is often listed beside it under similar names.
Specific rotation
Check that the rotation falls inside the stated range, often −9.8° to −11.2°. It is the quickest paper check that you are buying the L-form.
Production route
Ask whether the lot was made by fermentation or by another route, and what raw materials went in. Vegan and animal origin statements depend on the answer.
A spec written for amino acids
Amino acid sheets usually set loss on drying near 0.3%. A 5% limit or a 100,000 cfu/g plate count points to a botanical template, so ask for a corrected spec.
Other amino acids
Ask for the result for other amino acids and related substances by chromatography. Good sheets report them as not detectable or give a single impurity limit.
Contaminant limits
Check lead, arsenic, cadmium, and mercury by ICP-MS, plus microbial limits by USP methods. Compare each limit with your own finished product specification.
Label math: If you move a formula from N-acetyl-L-tyrosine to L-tyrosine, the gram weight changes. For example, 500 mg of tyrosine from NALT takes about 616 mg of NALT powder. Free form L-tyrosine at a 99% assay takes about 505 mg.
Typical specification for L-tyrosine
These values reflect published USP grade specifications. Final figures come from the specification sheet and COA for your lot. NLT means not less than, and NMT means not more than.
| Parameter | Specification | Method |
|---|---|---|
| Identity | L-tyrosine, C9H11NO3, CAS 60-18-4 | IR spectrum against a reference standard |
| Production | Microbial fermentation, or as stated on the COA | Supplier declaration |
| Appearance | White crystalline powder | Visual |
| Assay (dried basis) | 98.5 to 101.5% | Titration or HPLC |
| Specific rotation | −9.8° to −11.2° | USP <781S> |
| Other amino acids | Not detectable, or any single impurity NMT 0.5% | Chromatography |
| Loss on drying | NMT 0.3% | USP <731> |
| Residue on ignition | NMT 0.4% | USP <281> |
| Chloride | NMT 0.04% | USP <221> |
| Sulfate | NMT 0.04% | USP <221> |
| Iron | NMT 30 ppm | USP <241> |
| Lead | NMT 3 ppm, with lot result | ICP-MS |
| Arsenic | NMT 1.5 ppm | ICP-MS |
| Cadmium and mercury | NMT 1 ppm and NMT 0.1 ppm | ICP-MS |
| Particle size | 99% through 40 mesh | USP <786> |
| Total aerobic count | NMT 1,000 cfu/g | USP <2021> |
| Yeast and mold | NMT 100 cfu/g | USP <2021> |
| E. coli and Salmonella | Negative | USP <2022> |
| Retest period | 24 to 36 months from manufacture, unopened | Stability data |
Storage and handling for bulk L-tyrosine
Amino acid powders stay in good condition when they are sealed, dry, and at room temperature. These steps keep the powder in good condition between production runs.
Keep it sealed
Close the inner liner after each use and press out the air. An open bag can pick up moisture in a humid room and start to clump.
Store cool and dry
Keep bags off the floor in a dry room, away from heat and direct sunlight. Follow the temperature range on the spec sheet.
Control fine dust
Fine crystals can drift when you scoop or pour. Use local dust extraction and the protective equipment listed on the safety data sheet.
Rotate stock
Record the lot number and retest date for each bag. Send older lots to production first.
L-tyrosine buyer FAQ
Quick answers to the questions procurement and quality teams ask most.
What is the difference between L-tyrosine and N-acetyl-L-tyrosine?
L-tyrosine is the amino acid on its own, while N-acetyl-L-tyrosine (NALT) has an acetyl group attached. NALT is about 81% tyrosine by weight and dissolves more readily in water. This page covers free form L-tyrosine only.
Does L-tyrosine dissolve in water?
Only poorly. Published sheets describe L-tyrosine as very slightly soluble in plain water, so it stays as a fine suspension. Capsules, tablets, and dry blends are the easiest formats, and drink mixes need your own suspension trials.
What specific rotation should L-tyrosine have?
Published specifications call for about −9.8° to −11.2°. A result inside that range confirms the L-form, while a racemic DL material would read near zero.
How is L-tyrosine made?
L-tyrosine is made by microbial fermentation or by older extraction and synthesis routes, then purified and crystallized. Ask your supplier to name the route and any animal derived raw material.
Is there a USP monograph for tyrosine?
Yes. USP grade L-tyrosine is sold against the USP monograph, and spec sheets use its assay and rotation ranges. Ask whether your lot is tested against it.
What documents can I get with an order?
A certificate of analysis (COA) and a specification sheet ship with every order. An allergen statement and a safety data sheet may also be available, depending on the lot in inventory. Contact us to request them.
Can I get a sample before a bulk order?
You can request one by choosing sample options on the quote form. We will confirm availability, size, and timing.
Request a quote for bulk L-tyrosine powder
Tell us your quantity, grade, and timing. We will reply with current pricing. Select testing documents and sample options on the quote form.
Order L-Tyrosine PowderBulk orders: Choose a pack size above, or use the quote form for larger volumes, testing documents, and sample options. We serve supplement brands, contract manufacturers, product developers, and formulators.
This bulk ingredient is sold for further manufacturing and formulation. The information on this page describes the ingredient and how commercial buyers evaluate it. It is not medical advice. Each finished product brand is responsible for its own labeling and product claims.
