Wholesome in bulk™ Trans-Resveratrol Powder
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Bulk Trans-Resveratrol Powder for Supplement Manufacturing
Trans-resveratrol is an off white crystalline powder made from Japanese knotweed root (Reynoutria japonica, also sold as Polygonum cuspidatum) or by chemical synthesis. The usual bulk grade is NLT 98% trans-resveratrol by HPLC. We supply it in bulk to supplement brands, contract manufacturers, and formulators. You can request testing documents and samples on the quote form.
A single stilbene with a clear purity standard
Bulk resveratrol is sold by its trans-resveratrol content, measured by HPLC. That number, plus the source and the emodin result, lets you compare lots and suppliers on equal terms.
Defined chemical identity
Trans-resveratrol is C14H12O3, a stilbene with CAS number 501-36-0. Identity is confirmed by HPLC retention time against a reference standard.
Three production routes
Most bulk material is extracted from knotweed root and purified. Synthetic and yeast fermentation grades are also made, and each route has its own impurity profile.
Graded by purity
The most widely listed grade is NLT 98% trans-resveratrol. Extracts sold at 50% carry more of the other root compounds, so they need a fuller impurity check.
Emodin on the spec
Knotweed root also contains emodin, an anthraquinone. Good spec sheets set an emodin limit by HPLC, such as NMT 0.5%.
Light sensitive molecule
UV light converts trans-resveratrol into its cis form. Opaque packaging and short light exposure during handling keep the assay where it started.
Suited to dry formats
Trans-resveratrol dissolves poorly in water and well in ethanol. It fits capsules and tablets most easily.
Where formulators use trans-resveratrol
This compound fits measured formats where fill weight and light exposure are controlled, including:
- Capsules
- Compressed tablets
- Softgels with a suspension fill
- Single ingredient powders
- Multiple ingredient capsule blends
- Polyphenol and botanical blends
- Powdered drink mixes, after dispersion trials
- Private label programs
Plan fill weights from the assay on each COA. A 98% grade and a 50% grade are not interchangeable gram for gram, so recalculate your serving math whenever you change grades or sources.
What to check before you buy trans-resveratrol
Two powders sold as resveratrol can differ in source, purity, and impurity profile. Review these points together, and ask for lot documents before you approve a supplier.
Source and route
Confirm knotweed root extract, synthesis, or fermentation on both the spec sheet and the certificate of analysis (COA). The route shapes the impurity profile and the regulatory file.
Trans-resveratrol by HPLC
Ask for trans-resveratrol by HPLC, not total resveratrol or total polyphenols. The trans form is the one specs and labels name.
Emodin limit
For knotweed material, ask for an emodin result by HPLC on every lot. Compare it with the limit your own finished product specification sets.
Residual solvents
Knotweed extraction often uses ethyl acetate, ethanol, and water, and synthesis uses other process chemicals. Ask for GC results to USP <467>.
Contaminant limits
Check lead, arsenic, cadmium, and mercury by ICP-MS, and microbial limits by USP methods. Published limits for 98% material include lead at NMT 2 ppm.
Packaging that blocks light
Ask for opaque inner liners in a fiber drum and a stated retest date. Clear liners in a lit warehouse can shift the trans to cis ratio.
Label math: Name trans-resveratrol on your label and base the amount on each lot's measured assay. A stated grade is a minimum, so the figure on the COA is the one to work from, backed by your own finished product testing.
Typical specification for trans-resveratrol 98%
These values reflect published spec sheets for knotweed derived trans-resveratrol. Final figures come from the specification sheet and COA for your lot. NLT means not less than, and NMT means not more than.
| Parameter | Specification | Method |
|---|---|---|
| Identity | Trans-resveratrol, C14H12O3, CAS 501-36-0 | HPLC retention time against a reference standard |
| Source | Reynoutria japonica (syn. Polygonum cuspidatum) root | Supplier declaration |
| Appearance | White to off white fine powder | Visual |
| Trans-resveratrol | NLT 98.0% | HPLC |
| Emodin | NMT 0.5% | HPLC |
| Extraction solvents | Ethyl acetate, ethanol, and water | Supplier declaration |
| Residual solvents | Meets USP <467> | GC |
| Particle size | NLT 95% through 80 mesh | USP <786> |
| Loss on drying | NMT 2.0% | USP <731> |
| Sulfated ash | NMT 2.0% | USP <281> |
| Bulk density | 0.35 to 0.50 g/mL | USP <616> |
| Lead | NMT 2.0 ppm | ICP-MS |
| Arsenic | NMT 1.0 ppm | ICP-MS |
| Cadmium | NMT 1.0 ppm | ICP-MS |
| Mercury | NMT 0.1 ppm | ICP-MS |
| Total aerobic count | NMT 1,000 cfu/g | USP <2021> |
| Yeast and mold | NMT 100 cfu/g | USP <2021> |
| E. coli and Salmonella | Negative in 10 g and 25 g | USP <2022> |
| Shelf life | 24 to 36 months, unopened, away from light | Stability data |
Quality standards for trans-resveratrol
Food regulators in the EU and Taiwan publish detailed specs for trans-resveratrol, and knotweed grades follow supplier specs built on HPLC. These texts give buyers clear numbers for purity, impurities, and metals.
EU spec for synthetic material
The EU Union list of novel foods sets a purity floor of 98 to 99% for synthetic trans-resveratrol. Total related substances must be NMT 0.5%, and any single one NMT 0.1%. Lead and arsenic are capped at 1.0 ppm and mercury at 0.1 ppm. Loss on drying is NMT 0.5%, and sulfated ash NMT 0.1%.
EU spec for yeast fermented material
The same list covers trans-resveratrol made by a genetically modified Saccharomyces cerevisiae yeast. It must hold NLT 98% w/w on the dry basis, with ash NMT 0.5% and moisture NMT 3%. In 2022 the EU dropped an earlier rule that all particles of this grade be under 62.23 µm.
Other national specs
Canada's 2025 monograph allows trans-resveratrol from Reynoutria japonica root, Vitis vinifera fruit, or synthesis. Taiwan's 2023 draft for a fermented grade sets NLT 98% on the dry basis, lead under 1 ppm, and arsenic under 1.5 ppm. It also requires PCR tests that find no genetically modified organism or transgene in the powder.
HPLC that separates the isomers
A published C18 HPLC method separates trans and cis resveratrol, emodin, and quercetin within 15 minutes. UV readings can run falsely high once trans-resveratrol has started to break down. So specs and stability work should rely on HPLC, which tells the isomers apart.
Anthraquinones and polydatin
Knotweed root holds emodin and the related anthraquinones chrysophanol and physcion, which one HPLC method measures together at 287 nm. It also holds polydatin, the glucoside form of resveratrol. Some testing programs count polydatin at 0.587 times its weight as resveratrol, so ask whether a figure covers free trans-resveratrol only.
Sourcing and processing practices for trans-resveratrol
The three production routes leave different traces in the powder. These practices tell QA teams what to ask for on each route.
Know the conversion step
Knotweed root holds much of its resveratrol as polydatin, so makers convert it before purifying. In one lab report, 1.5 M hydrochloric acid in 85% ethanol at 70 °C for 5 hours gave about 86% yield. In another, a β-glucosidase enzyme converted 95.3% of crude polydatin in 4 hours. Ask which route was used and which solvents it leaves behind.
Ask for the extract ratio
One 98% knotweed grade states an extract ratio of 150:1, so 150 kg of root goes into each kilogram. Ask for the ratio on every lot. Pair it with the country where the root was grown and the country where it was extracted.
Document the synthetic route
Synthetic grades come from a multistep chemical process. The EU spec caps the process chemical diisopropylamine at NMT 50 mg/kg and each byproduct at NMT 0.1%. Ask for results on each named process impurity as well as purity.
Document the fermentation route
Fermented grades are made by an engineered yeast. Ask for the strain identity, the GMO status statement, and PCR results that show no production organism in the powder. Buyers in the EU and Taiwan check these records against their novel food rules.
Keep wet steps acidic
Trans-resveratrol in solution stays stable at acidic pH, but breakdown rises steeply above pH 6.8. Keep any liquid, gummy, or wet granulation step below that pH. Keep the batch out of direct light while it is wet.
Formulator tips for trans-resveratrol
Use these points when you set label figures, fill weights, and incoming tests. Most figures below come from regulatory specs and published supplier sheets.
- Plan capsule fill from bulk density. At 0.35 to 0.50 g/mL, 500 mg takes about 1.0 to 1.4 mL of fill volume, so ask for the lot value before you choose a capsule size.
- Ask for cis-resveratrol on the COA. One published spec caps it at NMT 1.0% by HPLC, which gives you a baseline for stability checks.
- Use melting point as a quick cross check at receiving. Trans-resveratrol melts at about 253 to 255 °C.
- Run stability on HPLC, not UV. UV totals can read high once trans-resveratrol starts to break down, which hides real loss.
- Do the metals math at your intake. At 500 mg a day, lead at 2.0 ppm gives 1.0 µg, and lead at 1.0 ppm gives 0.5 µg. Compare the result with your finished product limit.
- Set an incoming test plan. Run HPLC identity with trans and cis, emodin for knotweed lots, and related substances for synthetic lots. Add residual solvents by GC and lead by ICP-MS for each new supplier.
- Recheck trans and cis by HPLC at the retest date. Keep retained samples in the dark, so they match the stock in the warehouse.
Helping shoppers read a resveratrol label
Customer service teams hear the same few questions about resveratrol labels. These answers stick to what the ingredient is and how it is labeled.
What trans-resveratrol on a label means
Trans-resveratrol is the form of the molecule that specs and most labels name. A label may add the source, such as Japanese knotweed root (Polygonum cuspidatum). A line such as resveratrol 50% means half the extract weight is resveratrol.
Same molecule, three routes
Trans-resveratrol from knotweed root, from fermentation, or from synthesis is the same molecule. The route changes the trace compounds a maker tests for, such as emodin in knotweed grades. Brands can answer route questions from their supplier file.
Independent quality programs
Programs such as the USP Dietary Supplement Verification Program and NSF/ANSI 173 certification check finished products against their labels and contaminant limits. Independent labs measure trans-resveratrol by HPLC, and some add polydatin to the total.
Normal look and home storage
The powder is white to off white, and a fermented grade may look slightly yellow. Keep the bottle closed tightly, away from light and heat, since light turns part of the trans form into cis.
Storage and handling for bulk trans-resveratrol
Trans-resveratrol stays in spec longest in the dark, sealed, and dry. Light is the main risk here, because UV exposure changes the shape of the molecule.
Keep away from light
Leave the powder in its original opaque liner and drum. Weigh and blend promptly, away from direct sunlight, and close the liner between uses.
Keep it sealed
Press out the air before you close the liner. Supplier spec sheets ask for storage away from oxygen as well as light.
Store cool and dry
Keep drums off the floor in a dry room, away from heat sources. Follow the temperature range on the spec sheet.
Rotate and retest
Record the lot number and retest date for each drum. Send older lots to production first, and retest the assay on stock held near its retest date.
Trans-resveratrol buyer FAQ
Quick answers to the questions procurement and quality teams ask most.
What is the difference between 50% and 98% resveratrol?
A 98% grade is nearly all trans-resveratrol, while a 50% grade is a knotweed extract in which about half the weight is other root compounds. The 50% grade costs less per kilogram but needs twice the fill weight and a closer look at emodin. The 98% grade is the most widely listed.
What is emodin, and why is it on the spec?
Emodin is an anthraquinone that occurs naturally in knotweed root alongside resveratrol. Purification removes most of it, and spec sheets set a limit by HPLC, such as NMT 0.5%. Ask for the result on each lot.
What is the difference between trans- and cis-resveratrol?
They are two shapes of the same molecule. Trans-resveratrol is the form sold in bulk and named on specs, and UV light can convert part of it to the cis form. For this reason, use packaging that blocks light.
Is synthetic trans-resveratrol different from knotweed material?
The molecule is the same, but the route and impurity profile differ. Synthetic grades carry limits for process chemicals, while knotweed grades carry an emodin limit. In the EU, synthetic and yeast fermented trans-resveratrol are authorized novel foods, each with its own spec.
Does trans-resveratrol dissolve in water?
Only slightly. Trans-resveratrol dissolves poorly in water and well in ethanol, so it suits capsules and tablets. Drink formats need dispersion and settling trials.
Is there an official specification for trans-resveratrol?
Yes, for some sources. The EU Union list of novel foods sets specs for synthetic and yeast fermented trans-resveratrol. Each calls for NLT 98% purity, and the synthetic entry adds limits for metals and byproducts. Knotweed grades are specified by each supplier, usually NLT 98% by HPLC with an emodin limit.
What documents can I get with an order?
A certificate of analysis (COA) and a specification sheet ship with every order. An allergen statement and a safety data sheet may also be available, depending on the lot in inventory. Contact us to request them.
Can I get a sample before a bulk order?
You can request one by choosing sample options on the quote form. We will confirm availability, size, and timing.
How should I store an opened drum?
Close the liner, press out the air, and keep the drum in a cool, dark, dry place. Use the powder within the retest date or shelf life shown on the COA.
Request a quote for bulk trans-resveratrol
Tell us the grade, source, quantity, and timing you need. We will reply with current pricing. Select testing documents and sample options on the quote form.
Order ResveratrolBulk orders: Choose a pack size above, or request a quote for larger volumes, samples, and lot documents. We serve supplement brands, contract manufacturers, product developers, and formulators.
This bulk ingredient is sold for further manufacturing and formulation. The information on this page describes the ingredient and how commercial buyers evaluate it. It is not medical advice. Each finished product brand is responsible for its own labeling and product claims.
