Wholesome in bulk™ L-Glutamine Powder
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Bulk L-Glutamine Powder for Supplement Manufacturing
L-glutamine is a white crystalline powder made by bacterial fermentation, with sugar as the carbon source. It is the amide form of L-glutamic acid and has a slightly sweet taste. Supplement grades are sold at 98.5 to 101.5% by HPLC, with specific rotation to confirm the L-form. We supply it in bulk to supplement brands, contract manufacturers, and formulators. You can request testing documents and samples on the quote form.
A fermented amino acid for dry powder formulas
L-glutamine is a single amino acid with a narrow assay window and standard identity tests. It is easiest to work with in dry formats. These are the properties quality teams look at first.
Made by fermentation
Industrial L-glutamine comes from bacterial fermentation, often with Corynebacterium glutamicum strains, using sugar as the carbon source. Fermentation gives the L-form directly.
Tight assay window
Specs usually call for 98.5 to 101.5% by HPLC and a specific rotation of +6.3° to +7.3°. Identity is confirmed by infrared spectrum against a reference standard.
Fine, light powder
Common grades pass 120 mesh, with a bulk density near 0.5 to 0.6 g/mL. Fine powder suits capsules, stick packs, and dry blends.
Clean, mild taste
L-glutamine is white and odorless, with a slightly sweet taste. It blends into unflavored and flavored powders.
Stable when dry
As a dry powder it carries a 2 year shelf life on published spec sheets. In water it slowly turns into pyroglutamic acid and ammonia, so liquid formats need stability work.
Clear solution test
Grade specs include a light transmittance test, often NLT 98%. It is a quick check that a test solution is clear and colorless.
Where formulators use L-glutamine
L-glutamine fits measured dry formats where the serving size is controlled, including:
- Single ingredient powders
- Sports nutrition powders
- Protein powders and blends
- Powdered drink mixes
- Stick packs and sachets
- Capsules
- Compressed tablets
- Private label programs
Keep L-glutamine in dry formats where you can. In liquids it slowly converts to pyroglutamic acid and ammonia, so test any ready to drink product for glutamine content across its shelf life.
What to check before you buy L-glutamine
L-glutamine lots can share a name and still differ in standard, microbial testing, metals limits, and packaging. Review these points together, and ask for lot documents before you approve a supplier.
Assay and rotation
Confirm assay by HPLC within 98.5 to 101.5% and specific rotation within +6.3° to +7.3°. Both should appear on every COA with measured results.
Standard cited
Ask which standard the lot meets, such as USP, FCC, or an internal standard. One published COA cited an 'enterprise' standard and was marked as a translation.
Microbial reporting limits
Check that each result can show conformance. One published COA reported coliforms as less than 20 cfu/g against a 10 cfu/g limit, so the result could not confirm the limit.
Heavy metal limits
Published lead limits run from 3 to 5 mg/kg, and some sheets give only a 10 ppm total heavy metals limit. L-glutamine is used by the gram, so ask for ICP-MS lot results for each metal.
Origin and route
Ask for the country of manufacture and written confirmation of fermentation. Ask for the allergen statement and the supplier's statement on fermentation inputs.
Packaging
Ask how the lot is packed. Paper drums with double PE liners are common for 25 kg lots, and some packers flush bags with nitrogen.
Liquid formats: If you plan a ready to drink product, budget for stability testing. A powder that meets spec can fall below label once it sits in a liquid. Measure it again at the end of shelf life.
Typical specification for L-glutamine
These values reflect common market specifications for L-glutamine. Final figures come from the specification sheet and COA for your lot. NLT means not less than, and NMT means not more than.
| Parameter | Specification | Method |
|---|---|---|
| Identity | L-glutamine, C5H10N2O3, CAS 56-85-9 | IR spectrum against reference standard |
| Appearance | White crystalline powder, odorless, slightly sweet | Visual and sensory |
| Assay | 98.5 to 101.5% | HPLC |
| Specific rotation | +6.3° to +7.3° | USP <781> |
| Transmittance | NLT 98.0% | UV-Vis |
| Loss on drying | NMT 0.3% | USP <731> |
| Residue on ignition | NMT 0.1% | USP <281> |
| Particle size | NLT 95% through 120 mesh | USP <786> |
| Bulk density | NLT 0.50 g/mL | USP <616> |
| Lead | NMT 3 mg/kg | ICP-MS |
| Arsenic | NMT 1 mg/kg | ICP-MS |
| Cadmium | NMT 1 mg/kg | ICP-MS |
| Mercury | NMT 0.1 mg/kg | ICP-MS |
| Total aerobic count | NMT 1,000 cfu/g | USP <2021> |
| Yeast and mold | NMT 100 cfu/g | USP <2021> |
| E. coli and Salmonella | Negative | USP <2022> |
| Shelf life | 24 months, unopened | Stability data |
Storage and handling for bulk L-glutamine
L-glutamine keeps well as a dry powder in a closed container at room temperature. These steps keep the powder in good condition between production runs.
Keep it sealed
Close the inner liner after each use and press out the air. Fine powders pick up moisture from humid air and can cake when left open.
Store cool and dry
Keep drums and bags off the floor in a dry room at room temperature. Follow the range on the spec sheet.
Keep hold times short
If you dissolve L-glutamine during production, mix the solution close to filling. Glutamine converts slowly in water, so long holds can shift your assay.
Rotate stock
Record the lot number and retest date for each bag. Send older lots to production first.
L-glutamine buyer FAQ
Quick answers to the questions procurement and quality teams ask most.
How is L-glutamine made?
L-glutamine is made by bacterial fermentation, with sugar as the carbon source. The amino acid is then recovered from the broth as a crystalline powder.
Is L-glutamine stable in drinks?
Not over long periods. In water, L-glutamine slowly breaks down into pyroglutamic acid and ammonia. Dry powders are the usual format, and liquids need stability testing.
What specific rotation should L-glutamine have?
Typical specifications call for +6.3° to +7.3°. The test confirms the L-form and flags gross contamination, so ask for the measured result on each COA.
What mesh is bulk L-glutamine?
Common grades are fine powders, with NLT 95% through 120 mesh on one published specification. Ask for the sieve result and bulk density if fill weight matters.
What documents can I get with an order?
A certificate of analysis (COA) and a specification sheet ship with every order. An allergen statement and a safety data sheet may also be available, depending on the lot in inventory. Contact us to request them.
Can I get a sample before a bulk order?
You can request one by choosing sample options on the quote form. We will confirm availability, size, and timing.
How should I store an opened bag?
Close the liner, press out the air, and keep the bag in a cool, dry place. Use the powder within the shelf life shown on the COA.
Request a quote for bulk L-glutamine powder
Tell us your grade, quantity, and timing. We will reply with current pricing. Select testing documents and sample options on the quote form.
Order L-Glutamine PowderBulk orders: Choose a pack size above, or use the quote form for larger volumes, testing documents, and sample options. We serve supplement brands, contract manufacturers, product developers, and formulators.
This bulk ingredient is sold for further manufacturing and formulation. The information on this page describes the ingredient and how commercial buyers evaluate it. It is not medical advice. Each finished product brand is responsible for its own labeling and product claims.
