Wholesome in bulk™ Acetyl-L-Carnitine HCl Powder (ALCAR HCl)
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Bulk Acetyl-L-Carnitine HCl Powder for Supplement Manufacturing
Acetyl-L-carnitine HCl is a white crystalline powder made by adding an acetyl group to L-carnitine and isolating it as the hydrochloride salt. It is also sold as ALCAR HCl, and it is about 85% acetyl-L-carnitine by weight. We supply it in bulk to supplement brands, contract manufacturers, and formulators. You can request testing documents and samples on the quote form.
A salt form with a fixed formula and clear identity tests
Acetyl-L-carnitine HCl has one formula, a published assay range, and an optical rotation that confirms the L-form. Quality teams can compare lots line by line.
Known composition
The formula is C9H17NO4·HCl, with a molecular weight of 239.70. By weight, about 85% is acetyl-L-carnitine and about 15% is the hydrochloride.
L-form you can verify
Specific rotation on the COA confirms the L-form. Published specs set a narrow window of about -27° to -29°.
Standard identity tests
Good certificates of analysis (COAs) confirm identity by infrared spectroscopy (FT-IR) against a reference standard. They report the assay by HPLC, so you can compare lots directly.
White, water soluble crystals
Most lots are white crystalline powders. They dissolve in water to a clear, colorless solution with a pH of about 2.3 to 2.6, so expect a sour taste.
Consistent physical form
Published specs pass the powder through a 20 mesh screen, with a bulk density of about 0.3 to 0.7 g/mL. Check both figures against your capsule size and blend.
Traceable production
One published COA names the route as L-carnitine reacted with acetyl chloride. Suppliers can state the route, origin, and solvents used, which completes your supplier file.
Where formulators use acetyl-L-carnitine HCl
This salt fits measured formats where fill weight and serving size are controlled, including:
- Capsules
- Compressed tablets
- Single ingredient powders
- Multiple ingredient powder blends
- Powdered drink mixes
- Stick packs and sachets
- Gummies, after taste and stability trials
- Private label programs
Plan fill weights from the assay on each COA. About 1,180 mg of the HCl salt supplies 1,000 mg of acetyl-L-carnitine. State clearly whether your label figure refers to the salt or to the free compound.
What to check before you buy acetyl-L-carnitine HCl
Powders sold as acetyl-L-carnitine can differ in salt form, grade, and test method. Review these points together, and ask for lot documents before you approve a supplier.
Salt form on every document
Confirm acetyl-L-carnitine hydrochloride, CAS 5080-50-2, on both the specification and the COA. Other carnitine forms, such as L-carnitine L-tartrate, carry different active content.
Identity and the L-form
Look for FT-IR identity against a reference standard and a specific rotation inside the stated range. Ask the supplier to explain any result outside that window.
Free L-carnitine and chloride
In water, acetyl-L-carnitine can split back into L-carnitine and acetic acid. Ask whether the COA reports free L-carnitine and chloride, since many published specs leave both out.
Assay method and basis
Ask whether the assay is by HPLC or by titration, and whether it is on a dry or as is basis. The method and basis shift the number you put on a label.
Grade and documents
Supplement, pharmaceutical, and cosmetic grades are all traded. Confirm that your lot is sold for dietary supplement or food use and that the documents match that grade.
Solvents, contaminants, and origin
Check residual solvents by GC, heavy metals by ICP-MS, and microbial limits by USP methods. Ask for the country of manufacture and the producing plant for your supplier file.
Label math: If your label lists acetyl-L-carnitine per serving, work from the measured assay on each COA. One gram of the HCl salt supplies about 848 mg of acetyl-L-carnitine, or about 673 mg expressed as L-carnitine. State clearly which figure your label uses.
Typical specification for acetyl-L-carnitine HCl
These values reflect common published specifications for the hydrochloride salt. Final figures come from the specification sheet and COA for your lot. NLT means not less than, and NMT means not more than.
| Parameter | Specification | Method |
|---|---|---|
| Identity | Acetyl-L-carnitine hydrochloride, CAS 5080-50-2 | FT-IR against reference standard |
| Appearance | White crystalline powder | Visual |
| Assay (acetyl-L-carnitine HCl) | 98.0 to 101.0% | HPLC |
| Specific rotation | -27.0° to -29.0° | Polarimetry, USP <781> |
| pH (aqueous solution) | 2.3 to 2.6 | USP <791> |
| Loss on drying | NMT 0.5% | USP <731> |
| Residue on ignition | NMT 0.5% | USP <281> |
| Related substances, including free L-carnitine | NMT 1.5% total | HPLC |
| Chloride | Limit stated on the COA; formula value about 14.8% | Stated on the COA |
| Residual solvents | Ethanol NMT 0.5% | GC, USP <467> |
| Particle size | 100% through 20 mesh | USP <786> |
| Bulk and tapped density | 0.3 to 0.7 g/mL bulk, 0.5 to 0.9 g/mL tapped | USP <616> |
| Lead | NMT 3.0 ppm | ICP-MS |
| Arsenic | NMT 1.0 ppm | ICP-MS |
| Cadmium | NMT 1.0 ppm | ICP-MS |
| Mercury | NMT 0.1 ppm | ICP-MS |
| Total aerobic count | NMT 1,000 cfu/g | USP <2021> |
| Yeast and mold | NMT 100 cfu/g | USP <2021> |
| E. coli and Salmonella | Negative | USP <2022> |
| Shelf life | 24 months from manufacture, unopened | Stability data |
Storage and handling for bulk acetyl-L-carnitine HCl
Acetyl-L-carnitine HCl keeps best sealed, dry, and cool. Some producers store it refrigerated, so follow the temperature on the spec sheet for your lot.
Keep it sealed
Close the inner liner after each use and press out the air. Spec sheets advise keeping this salt away from moisture, and an open bag can cake.
Follow the sheet's temperature
Some spec sheets call for 2 to 8°C (36 to 46°F), away from light. Others allow a cool, dry room. Store each lot as its own sheet directs.
Watch pH in liquids
Acetyl-L-carnitine holds up in acidic to neutral water but breaks down quickly above pH 9. Keep liquid prototypes at or below neutral pH and run your own stability tests.
Rotate stock
Record the lot number and retest date for each bag. Send older lots to production first.
Acetyl-L-carnitine HCl buyer FAQ
Quick answers to the questions procurement and quality teams ask most.
How much acetyl-L-carnitine is in acetyl-L-carnitine HCl?
Acetyl-L-carnitine HCl is about 85% acetyl-L-carnitine by weight. The other 15% is the hydrochloride. These figures come from the formula weights, 239.70 for the salt and 203.24 for acetyl-L-carnitine.
What is the difference between acetyl-L-carnitine and L-carnitine?
Acetyl-L-carnitine is L-carnitine with an acetyl group attached. It is a separate compound with its own CAS number, assay, and specific rotation. Name the exact form on purchase orders, because the two are not interchangeable gram for gram.
How do I confirm the material is the L-form?
Check the specific rotation on the COA. Published specs for acetyl-L-carnitine HCl call for about -27° to -29°. You can also ask whether the supplier runs a chiral test for the D-form.
Does acetyl-L-carnitine HCl dissolve in water?
Yes. It dissolves to a clear, colorless solution with a pH of about 2.3 to 2.6. The taste is sour, so trial it with citrus or other acidic flavor systems.
Is acetyl-L-carnitine stable in liquid formulas?
It is stable in acidic to neutral water but breaks down above pH 9, where it splits into L-carnitine and acetic acid. Cool storage slows the change, so run stability tests in your own liquid base.
What documents can I get with an order?
A certificate of analysis (COA) and a specification sheet ship with every order. An allergen statement and a safety data sheet may also be available, depending on the lot in inventory. Contact us to request them.
Can I get a sample before a bulk order?
You can request one by choosing sample options on the quote form. We will confirm availability, size, and timing.
How should I store an opened bag?
Close the liner, press out the air, and keep the bag cool, dry, and away from light. Use the powder within the shelf life shown on the COA.
Request a quote for bulk acetyl-L-carnitine HCl
Tell us your grade, quantity, and timing. We will reply with current pricing. Select testing documents and sample options on the quote form.
Order Acetyl-L-Carnitine HClBulk orders: Choose a pack size above, or use the quote form for larger volumes, testing documents, and sample options. We serve supplement brands, contract manufacturers, product developers, and formulators.
This bulk ingredient is sold for further manufacturing and formulation. The information on this page describes the ingredient and how commercial buyers evaluate it. It is not medical advice. Each finished product brand is responsible for its own labeling and product claims.
