Wholesome in bulk™ Nattokinase Enzyme Powder
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Bulk Nattokinase Enzyme Powder for Supplement Manufacturing
Nattokinase is an enzyme powder made from soybeans fermented with Bacillus subtilis var. natto, the culture used for the Japanese food natto. Each grade is defined by enzyme activity in FU per gram rather than by weight. We supply it in bulk to supplement brands, contract manufacturers, and formulators. You can request testing documents and samples on the quote form.
A defined enzyme ingredient for capsule and tablet formulas
Nattokinase is specified by activity, not by percentage. A clear unit, a named assay, and a public benchmark specification make lot to lot comparison straightforward for buyers and quality teams.
Graded by activity
Specifications state nattokinase in FU (fibrin degradation units) per gram. The most widely listed grade is 20,000 FU/g, so a 100 mg fill carries about 2,000 FU.
A well characterized protein
Nattokinase is a serine protease of the subtilisin family, about 275 amino acids and 27.7 kDa. Its enzyme classification number is EC 3.4.21.62.
Fermentation origin
Producers ferment soybean with Bacillus subtilis var. natto, recover the enzyme by filtration, and dry it to a powder. The powder is then standardized to its stated activity, often with a dextrin carrier.
Vitamin K2 removed
Natto naturally contains vitamin K2 (menaquinone-7). Ingredient grade nattokinase is processed to remove it, and good specifications set a limit measured by HPLC.
Light, mild powder
Typical lots are off white to pale yellow with a faint odor. Carrier standardized grades dissolve or disperse readily in water for blending and testing.
Public benchmark specification
The EU authorized one branded fermented soybean extract in 2017 at 20,000 to 28,000 FU/g, with vitamin K2 NMT 0.1 mg/kg. That gives buyers a published reference for activity and composition.
Where formulators use nattokinase powder
This enzyme fits dry, measured formats where fill weight and activity per unit are controlled, including:
- Capsules
- Delayed release or acid resistant capsules
- Compressed tablets, including enteric coated tablets
- Softgels, as an oil suspension
- Single ingredient powders for encapsulation
- Multiple ingredient capsule blends
- Private label programs
Plan fill weights from the FU result on each COA. Published stability data show activity holds well in dry powder. It drops in solutions below pH 5.0, so acidic liquid bases and gummies need their own trials. Many brands add an overage based on supplier stability data.
What to check before you buy nattokinase powder
Two powders labeled 20,000 FU/g can differ in assay method, carrier, and source. Review these points together, and ask for lot documents before you approve a supplier.
Activity unit and method
Confirm the result is in FU per gram and ask which assay produced it. The fibrin degradation method reads UV absorbance at 275 nm. Fibrin plate, synthetic substrate, and IU results do not convert directly to FU.
Activity over shelf life
Ask for stability data showing FU at release and at the end of the stated shelf life. Use it to set your overage and retest dates.
Carrier and composition
Ask what carrier is used to reach the stated activity, and at what percentage. Resistant dextrin and maltodextrin from corn are both common.
Vitamin K2 result
Confirm that vitamin K2 (menaquinone-7) was removed and that each COA reports a result by HPLC. A limit of NMT 0.1 mg/kg is the published EU benchmark.
Soy source and allergen statement
Nattokinase is usually fermented on soybean. Make sure the allergen statement matches the substrate named on the specification, and ask for a non-GMO soybean declaration if you need one.
Microbial and metals limits
Check heavy metals by ICP-MS, microbial limits by USP methods, and a limit for spore forming bacteria. The production organism is a spore former, so check this row closely for enzyme powders.
Label math: If your label lists FU per capsule, base it on each lot's measured activity. Confirm it with your own finished product testing at the end of shelf life. Enzyme activity can drift in storage, so plan your overage from stability data rather than the release COA alone.
Typical specification for nattokinase powder
These values reflect the common 20,000 FU/g grade. Final figures come from the specification sheet and COA for your lot. NLT means not less than, and NMT means not more than.
| Parameter | Specification | Method |
|---|---|---|
| Source | Bacillus subtilis var. natto fermentation of soybean (Glycine max) | Supplier declaration and strain records |
| Appearance | Off white to pale yellow fine powder | Visual |
| Odor | Faint, characteristic | Organoleptic |
| Nattokinase activity | NLT 20,000 FU/g | Fibrin degradation method, UV at 275 nm |
| Vitamin K2 (menaquinone-7) | Not detected, NMT 0.1 mg/kg | HPLC |
| Carrier | Resistant dextrin or maltodextrin, named with percentage on the specification sheet | Supplier declaration |
| Allergen statement | Soy derived; declaration per lot | Supplier declaration |
| Particle size | Mesh size per spec sheet | USP <786> |
| Loss on drying | NMT 7.0% | USP <731> |
| Lead | NMT 2.0 ppm | ICP-MS |
| Arsenic | NMT 3.0 ppm | ICP-MS |
| Cadmium | NMT 1.0 ppm | ICP-MS |
| Mercury | NMT 0.1 ppm | ICP-MS |
| Total aerobic count | NMT 10,000 cfu/g | USP <2021> |
| Yeast and mold | NMT 1,000 cfu/g | USP <2021> |
| Spore forming bacteria | NMT 10 cfu/g | Plate count |
| E. coli and Salmonella | Negative in 10 g and 25 g | USP <2022> |
| Shelf life | 24 months, unopened | Stability data (FU retest) |
Storage and handling for bulk nattokinase
Enzyme powders hold their activity longest when they stay sealed, dry, and cool. These habits help you hold activity across several production runs and keep your blending room clean.
Keep it sealed
Close the inner liner after each use and press out the air. Enzyme powders pick up moisture from the air, and damp powder loses activity faster.
Store cool and dry
Keep bags off the floor in a dry room, away from heat sources. Follow the temperature range on the spec sheet, and keep the powder in its original foil packaging.
Control dust
Protease enzyme dust can sensitize workers who breathe it over time. Use local dust extraction, respiratory protection, and gentle transfer when you weigh and blend.
Rotate stock
Record the lot number and retest date for each bag. Send older lots to production first, and retest FU on any lot held past its retest date.
Nattokinase powder buyer FAQ
Quick answers to the questions procurement and quality teams ask most.
What does FU mean on a nattokinase specification?
FU stands for fibrin degradation units, the activity unit used for nattokinase. The assay incubates the enzyme with a fibrin substrate at 37 °C and reads the released fragments by UV absorbance at 275 nm. A higher FU per gram means more enzyme activity in each gram of powder.
Which grade should I choose?
Most buyers choose 20,000 FU/g, the most widely listed grade. At that grade, 100 mg of powder carries about 2,000 FU. Choose based on your label target per capsule, capsule size, and cost per finished unit.
Can I compare FU values from two suppliers?
Only when both use the same assay method and reference standard. Results from fibrin plate, synthetic substrate, or IU methods do not convert directly to FU. Ask each supplier to name the method on the COA.
Is nattokinase made from soy?
Yes, it is usually produced by fermenting soybeans with Bacillus subtilis var. natto. Soy is a major food allergen in the US, so confirm the allergen statement for your lot. A non-GMO declaration and an allergen statement may be available depending on the lot, so please confirm with us before you order.
Has the vitamin K2 been removed?
Ingredient grade nattokinase is normally processed to remove vitamin K2, and each COA should report the result. The published EU benchmark limit is NMT 0.1 mg/kg.
What documents can I get with an order?
A certificate of analysis (COA) and a specification sheet ship with every order. An allergen statement and a safety data sheet may also be available, depending on the lot in inventory. Contact us to request them.
Can I get a sample before a bulk order?
You can request one by choosing sample options on the quote form. We will confirm availability, size, and timing.
How should I store an opened bag?
Close the liner, press out the air, and keep the bag in a cool, dry place. Weigh it under dust extraction, and retest FU on any lot held past its retest date.
Request a quote for bulk nattokinase powder
Tell us your activity grade, quantity, and timing. We will reply with current pricing. Select testing documents and sample options on the quote form.
Order Nattokinase PowderBulk orders: Choose a pack size above, or use the quote form for larger volumes, testing documents, and sample options. We serve supplement brands, contract manufacturers, product developers, and formulators.
This bulk ingredient is sold for further manufacturing and formulation. The information on this page describes the ingredient and how commercial buyers evaluate it. It is not medical advice. Each finished product brand is responsible for its own labeling and product claims.
